Long-term treatment of sulphonylurea-treated diabetics with the ?-glucosidase inhibitor Bay g 5421 (Acarbose)
نویسندگان
چکیده
منابع مشابه
Effects of acarbose, an alpha-glucosidase inhibitor (Bay G 5421), on orally loaded glucose, maltose and sucrose and on blood glucose control in non-insulin-dependent diabetics.
Fifty g glucose, 50g maltose and 50g sucrose were loaded to 12 nonobese healthy male volunteers with and without 100 or 300 mg a-glucosidase inhibitor, acarbose, and the inhibitory effect on digestion and absorption of these saccharides was studied. In another series of investigations, acarbose 100 mg a day were orally administered to 12 non-insulin-dependent diabetics for 3 months together wit...
متن کاملLong-term treatment in diabetics with acarbose, a glucosidase inhibitor: efficacy, tolerability and effect on GI hormones.
12 months therapy with acarbose in 143 type I and type II patients markedly improved the metabolic control, assessed by fasting and postprandial blood glucose determination. During 5 year acarbose treatment GIP levels were decreased and enteroglucagon levels were elevated. After withdrawal of the drug for one week GIP levels increased and enteroglucagon concentrations fell. Thus, GI-hormone cha...
متن کاملAcarbose, an -Glucosidase Inhibitor, Attenuates Postprandial Hypotension in Autonomic Failure
Postprandial hypotension is an important clinical condition that predisposes to syncope, falls, angina, and cerebrovascular events. The magnitude of the fall in blood pressure after meals depends on enteric glucose availability. We hypothesized that acarbose, an -glucosidase inhibitor that decreases glucose absorption in the small intestine, would attenuate postprandial hypotension. Acarbose or...
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15 صفحه اولEffect of sulphonylurea on insulin secretion and glucose control in insulin-treated diabetics.
past year. In four cases bone-marrow suppression was limited to the myeloid compartment,'-4 whereas in the present case, as in the one reported by Gavras et al,5 the erythroid and megakaryocytic cell lines were all suppressed. In four cases, as in ours, the patients had renal insufficiency. Since captopril is eliminated by the kidney, toxic concentrations of the drug may have developed. Other d...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1981
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00252772